Effects of alcohol abuse

See the separate related articles Alcoholism and Alcohol Misuse - Recognition and Assessment and Alcoholism and Alcohol Dependence (Management).

The recommended maximum alcohol intake per week is 14 units for men and 14 units for women.

In 2018, men and women aged 55 to 64 had the highest proportions of alcohol intake, usually drinking over 14 units in a week. 38% of men and 19% of women aged 55 to 64 usually drank over 14 units in a week¹ .

Morbidity and mortality statistics for alcohol abuse¹

In 2018-19, there were an estimated 358,000 admissions where the main reason for admission was drinking alcohol (6% higher than 2017/18 and 19% higher than 2008/09).

There were 5,698 alcohol-specific deaths in 2018 (2% lower than 2017 and an increase of 7% on 2008).

Short-term harm related to alcohol abuse^{2 3}

• Death and illness from accident and injury, drowning, alcohol poisoning, and self-harm related to alcohol.

• Drinking five UK units on a single occasion more than doubles the relative risk of an injury in the six hours afterwards, and this relative risk rises even more rapidly when higher levels are consumed.

Long-term harm related to alcohol abuse^{2 3}

Cancer⁴

• Increased risk of some cancers, including:

  • Cancers of the oral cavity.

  • Laryngeal cancer.

  • Oesophageal cancer.

  • Colorectal cancer.

  • Gastric cancer.

  • Liver cancer.

  • Breast cancer.

• For female breast cancer, relative risks of both illness and death increase by 16% if drinking regularly at 2 units per day and by 40% if drinking regularly at 5 units per day.

• The lifetime risk of bowel cancer in men who drink at least 35 units weekly is almost double that of men who do not drink alcohol.

Cardiovascular disease⁵

• Atrial fibrillation.

• Hypertension: Excessive alcohol use is associated with hypertension and subsequent target organ damage such as strokes, myocardial events and chronic kidney disease.

• Dilated cardiomyopathy with heart failure.

For cardiac arrhythmias in men, relative risks of illness and death from the disease increase by 13% if drinking regularly at 2 units per day and by 34% if drinking regularly at 5 units per day.

Liver disease⁶

Alcohol accounts for over a third of all cases of liver disease. The three conditions most associated with alcohol use are fatty liver (steatosis), hepatitis (acute hepatitis and chronic hepatitis), and cirrhosis.

Alcoholic cirrhosis is associated with a significant increase in risk of death due to bleeding oesophageal varices, infection, renal failure, and/or liver failure.

For cirrhosis of the liver in men, relative risks of death from the disease increase by 57% if drinking regularly at 2 units per day and by 207% if drinking regularly at 5 units per day.

Gastrointestinal tract⁷

Alcohol increases the risk of oral cancers. This is especially associated with spirits and the risk is increased with concomitant use of tobacco. Adenocarcinoma of the stomach and oesophagus are thought to be related to alcohol use. Some of these cases may be genetically determined .

Portal hypertension is a complication of cirrhosis and leads to a raised venous pressure in veins in the oesophagus and stomach. These swollen veins are superficial and bleed easily. Bleeding from oesophageal varices is serious and is associated with a high level of morbidity and mortality .

Management of bleeding varices is a medical emergency and requires adequate resuscitation (patients may need to be intubated to protect their airway). Blood transfusions are necessary and correction of abnormal clotting with vitamin K and fresh frozen plasma (FFP) may also be required. Various options for treatment are available including vasoactive drugs, obturation with glue and balloon tube tamponade.

Both acute pancreatitis and chronic pancreatitis are associated with excessive alcohol consumption. One study found that consumption of spirits was more likely than wine or beer to cause acute pancreatitis. The pathophysiology of alcohol-related pancreatitis is not clearly understood. Patients usually present with epigastric pain with vomiting. The amylase is high in acute pancreatitis but may be normal in patients with chronic pancreatitis. Pancreatitis can be associated with a number of complications such as shock, sepsis and abscess formation. Long-term complications include diabetes mellitus and weight loss from steatorrhoea.

Nervous system⁸

Acute alcohol intoxication can present with blackouts, head injuries and subdural haemorrhages. Alcohol withdrawal is associated with fits which may be unresponsive to antiepileptics.

The Wernicke-Korsakoff syndrome results from lack of thiamine (commonly seen in those with alcohol dependency, due to malnutrition). Wernicke's syndrome occurs acutely and patients present with confusion, visual impairment (diplopia) and ataxia. Korsakoff's syndrome occurs more chronically and is characterised by memory deficits and confabulation .

Young people may be especially at risk of alcohol-induced brain impairment⁹ .

Other adverse effects on the neurological system include peripheral neuropathy and cerebellar degeneration.

Psychiatric illness

Psychiatric conditions associated with alcohol misuse include:

• Alcohol dependence syndrome

• Suicidal ideation

• Depression

• Anxiety

Approximately 44% of community mental health patients report problem drug use or harmful alcohol use in the previous year.

The national confidential inquiry into suicide and homicide by people with mental illness found that there was a history of alcohol misuse in 45% of suicides among the patient population during period 2002 to 2011.

Pregnancy

Alcohol consumption during pregnancy can adversely affect the fetus:

• Fetal alcohol exposure can cause miscarriage, stillbirth, and intrauterine growth restriction.

• Heavy drinking during pregnancy (repeatedly consuming more than around five units per day), can result in fetal alcohol spectrum disorders (FASD).

Sexual function¹⁰

Alcohol is associated with sexual dysfunction in men and women, including loss of libido and, in men, erectile dysfunction and premature or delayed ejaculation.

Social complications

• Social complications relating to alcohol misuse include:

  • Family conflict and domestic violence and abuse.

  • Impaired performance at work.

  • Relationship problems.

  • Violent crimes - eg, domestic violence and drink driving offences.

  • Antisocial behaviour.

Alcohol plays a part in 25-33% of known cases of child abuse.

In a study of four London boroughs, almost two thirds of all children subject to care proceedings had parents who misused substances, including alcohol.

In a study of young offending cases where the young person was also misusing alcohol, 78% had a history of parental alcohol abuse or domestic abuse within the family.

Miscellaneous problems associated with alcohol abuse

• Loss of libido

• Fetal alcohol syndrome

Alcohol withdrawal

Alcohol withdrawal symptoms occur within a few hours of not having a drink and can last beyond 48 hours. Patients experience hallucinations, anxiety and a coarse peripheral tremor. On examination, patients may be pyrexial, tachycardic and hypertensive. They may also develop seizures and auditory and visual hallucinations.

Delirium tremens is the severe end of the spectrum of alcohol withdrawal and consists of a severe form of the above symptoms; it may be associated with circulatory collapse and ketoacidosis.

See the separate Acute Alcohol Withdrawal and Delirium Tremens article for more details.

Alcohol dependence

This is characterised by the following:

• A strong desire to drink.

• Difficulty controlling alcohol intake.

• Physiological withdrawal when intake is reduced.

• Tolerance, such that increasing amounts are required to produce the same effect.

• Harm resulting from continued alcohol use - eg, work or relationship problems.

Treatment of alcohol dependence includes education, support, counselling and controlled alcohol withdrawal. Patients may need to be admitted to hospital for detoxification¹¹ .

See the separate Alcoholism and Alcohol Dependence - Management article for more details.